PHACS Sub-studies
See below for a list of active and closed substudies.
Active Sub-studies
Brain Imaging Sub-study
Principal Investigator:
Description: This sub-study of AMP looks at youth born with HIV to compare the differences in brain structure, as well as structural and functional connectivity across a range of cognitive abilities.
1. Lewis-de los Angeles CP, Williams PL, Huo Y, Wang SD, Uban KA, Herting MM, Malee K, Yogev R, Csernansky JG, Nichols S, Van Dyke RB, Sowell ER, and Wang L for the Pediatric HIV/AIDS Cohort Study and the Pediatric, Imaging, Neurocognition, and Genetics Study. Lower total and regional grey matter brain volumes in youth with perinatally-acquired HIV infection: associations with HIV disease severity, substance use, and cognition. Brain Behav Immun 2017; 62:100-109. PMCID: PMC 5373952.
2. Lewis-de los Angeles CP, Alpert KI, Williams PL, Malee K, Huo Y, Csernansky JG, Yogev R, Van Dyke RB, Sowell ER, and Wang L for the Pediatric HIV/AIDS Cohort Study (PHACS). Deformed subcortical structures are related to HIV disease severity in youth with perinatally-acquired HIV infection. J Pediatric Infect Dis Soc 2016; 5(suppl 1):S6-S14; PMCID: PMC5181545.
3. Herting MM, Uban KA, Williams P, Huo Y, Malee K, Yogev R, Csernansky J, Wang L, Nichols S, Van Dyke R, and Sowell ER for the Pediatric HIV/AIDS Cohort Study. Default mode connectivity in youth with perinatally-acquired HIV. Medicine 2015; 94(37):e1417; PMCID: PMC4635795.
4. Uban KA, Herting MM, Williams PL, Ajmera T, Gautam P, Huo Y, Malee KM, Yogev R, Csernansky JG, Wang Lei, Nichols SL, and Sowell ER for the Pediatric HIV/AIDS Cohort Study. White matter microstructure among youth with perinatally acquired HIV is associated with disease severity. AIDS 2015; 29(9):1035-44; PMCID: PMC4487416
Cardiac Sub-study
Principal Investigators:
Steven E. Lipshultz, MD
Russell Van Dyke, MD
Description: This sub-study follows up with infected and uninfected youth and young adults that have been actively followed within AMP and AMP Up. By comparing echocardiogram testing completed in 2010, this study hopes to determine whether infected youth and young adults with long term exposure to combination antiretroviral therapy are at increased risks of premature symptomatic cardiovascular disease.
Oral Health Sub-study
Principal Investigators:
Anna-Barbara Moscicki, MD
Mark I Ryder, DMD
Caroline H. Shiboski, DDS, PhD
Tzy-Jyun Yao, PhD
Description: This study looks at infected and uninfected youth to estimate and compare the prevalence and progression of dental, periodontal, and oral mucosal diseases, and their association with oral microbiota, as well as oral HPV infection.
1. Shiboski C, Yao TJ, Jonathan S. Russell J, Ryder M, Van Dyke R, Seage III G, Moscicki A-B for the Pediatric HIV/AIDS Cohort Study. The Association Between Oral Disease and Type of Antiretroviral Therapy among Perinatally HIV-Infected Youth. AIDS, 2018 Aug 8. doi: 10.1097/QAD.0000000000001965. [Epub ahead of print], PMID: 30096069.
2.Starr J, Huang Yanmei1, Lee KH, Murphy C, Moscicki A-B, Shiboski C, Ryder M, Yao TJ, Faller L, Van Dyke R, Paster B for the Pediatric HIV/AIDS Cohort Study. Oral microbiota in youth with perinatally acquired HIV infection. Microbiome 2018 May 31;6(1):100. doi: 10.1186/s40168-018-0484-6. PMID: 29855347
3.Ryder M, Yao TJ, Russell J, Moscicki A-B, and Shiboski C for the Pediatric HIV/AIDS Cohort Study. Prevalence of Periodontal Diseases in a Multicenter Cohort of Perinatally HIV-Infected and HIV-exposed and Uninfected Youth. J Clin Periodontol. 2016 Nov 1. doi: 10.1111/jcpe.12646. [Epub ahead of print] PMID: 27801947
4.Moscicki A-B, Farhat S, Yao TJ, Ryder M, Russell J, Van Dyke R, Hazra R, Shiboski C for the Pediatric HIV/AIDS Cohort Study. Oral human papillomavirus in youth from the Pediatric HIV/AIDS Cohort Study. Sex Transm Dis. 2016 Aug;43(8):498-500. doi: 10.1097/OLQ.0000000000000495. PMID: 27414680.
5.Moscicki A-B, Yao TJ, Ryder M, Russell J, Dominy S, Patel K, McKenna M, Van Dyke R, Seage G, Hazra R, Shiboski C for the Pediatric HIV/AIDS Cohort Study. The burden of oral disease among perinatally HIV-infected and HIV-exposed uninfected youth. PLoS One, 2016, Jun 14;11(6):e0156459. doi: 10.1371/journal.pone.0156459. eCollection 2016. PMID: 27299992
HPV Sub-study
Principal Investigators:
Anna-Barbara Moscicki, MD
Denise Jacobson, PhD, MPH
Description: This sub-study involves female youth enrolled in AMP or AMP Up with or without histologically-confirmed squamous intraepithelial lesions to compare colposcopic examinations findings and histologic diagnoses with HPV genotyping.
Closed Sub-studies
Memory Sub-study
Principal Investigator:
Description: This sub-study, involving youth enrolled in AMP, compared memory and executive functioning between infected and uninfected youth. Over a time period of two years, changes in memory and executive functioning and their relationship with daily functioning were also studied.
1. Garvie PA, Nichols SL, Williams PL, Harris LL, Kammerer B, Chernoff MC, Figueroa V, & Woods SP for the Memory and Executive Functioning Substudy of the Pediatric HIV/AIDS Cohort Study. Development, reliability, and initial construct validity of the Prospective Memory Assessment for Children & Youth (PROMACY) in a non-clinical sample. The Clinical Neuropsychologist (in press).
2. Harris LL, Chernoff MC, Nichols SL, Williams PL, Garvie PA, Yildirim C, McCauley SR, & Woods SP for the Pediatric HIV/AIDS Cohort Study. Prospective memory in youth with perinatally-acquired HIV infection. Child Neuropsychology 2017; Aug. 7:1-21 [epub ahead of print]
3. Malee KM, Chernoff MC, Sirois PA, Williams PL, Garvie PA, Kammerer BL, Harris LL, Nozyce ML, Yildirim C, & Nichols SL for the Pediatric HIV/AIDS Cohort Study. Impact of perinatally acquired HIV disease on longitudinal changes in memory and executive functioning. Journal of Acquired Immune Deficiency Syndrome 2017; 75(4): 455-464.
4. Sirois PA, Chernoff MC, Malee KM, Garvie PA, Harris LL, Williams PL, Woods SP, Nozyce ML, Kammerer BL, Yildirim C, & Nichols SL for the Memory and Executive Functioning Study of the Pediatric HIV/AIDS Cohort Study. Associations of memory and executive functioning with academic and adaptive functioning among youth with perinatal HIV exposure and/or infection. Journal of the Pediatric Infectious Diseases Society 2016; 5(Suppl1):S24-S32.
5. Nichols SL, Chernoff MC, Malee KM, Sirois PA, Williams PL, Figueroa V, & Woods SP for the Pediatric HIV/AIDS Cohort Study. Learning and memory in children and adolescents with perinatal HIV infection and perinatal HIV exposure. The Pediatric Infectious Disease Journal 2016; 35(6): 649-54.
Tenofovir Sub-study
Principal Investigators:
Denise Jacobson, PhD, MPH
George K. Siberry, MD, MPH
Description: This sub-study, involving newborns enrolled in SMARTT, compared levels of bone mineral content in the first month of life between newborns who were exposed compared to those not exposed to tenofovir in-utero.
1. Siberry GK, Jacobson DL, Kalkwarf HJ, Wu JW, DiMeglio LA, Yogev R, Knapp KM, Wheeler JJ, Butler L, Hazra R, Miller TL, Seage GR, Van Dyke RB, Barr E, Davtyan M, Mofenson LM, & Rich KC for the Pediatric HIV/ AIDS Cohort Study. Lower Newborn Bone Mineral Content Associated With Maternal Use of Tenofovir Disoproxil Fumarate During Pregnancy. Clin Infect Dis. 2015 Sep 15;61(6):996-1003. Doi:10.1093/cd/civ437. Epub 2015 Jun 9. PMID: 26060285